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Prostate Cancer treatment details. Biologic therapy. Massachusetts General Hospital, Boston, MA, United States



Survival: 10.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Massachusetts General Hospital
   
Journal: Link
   
Date: 10/2014

Description:
Patients:
This phase 2 study involved 144 metastatic castration-resistant prostate cancer patients who had received prior chemotherapy. The median patient age was 65 years.

Treatment:
Patients received biologic therapy with cabozantinib, a receptor tyrosine kinases inhibitor that interferes with cancer cell growth.

Toxicities:
There was one reported treatment-related death due to liver failure. Grade 3-4 fatigue, nausea, diarrhea, back pain, and anemia were also reported.

Results:
The median overall survival was 10.8 months.

Support:
This study was partially supported by Exelixis, makers of the study drug.

Correspondence: Dr. ; email: smith.matthew@mgh.harvard.edu

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