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Breast Cancer treatment details. Biologic therapy. Chemotherapy. University of Alberta, Edmonton, Alberta, Canada



Survival: 27.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Canada
   
City/State/Province: Edmonton, Alberta
   
Hospital: University of Alberta
   
Journal: Link
   
Date: 1/2015

Description:
Patients:
This phase 3 study involved female metastatic breast cancer patients who were divided into two separate treatment groups. Group A had 759 patients with a median age of 54 years, and group B had 385 patients with a median age of 54 years.

Treatment:
Patients in group A received chemotherapy with docetaxel and biologic therapy with ramucirumab (a monoclonal antibody that blocks the VEGFR-2 protein and interferes with cancer cell growth).

Patients in group B received chemotherapy with docetaxel and a placebo.

Toxicities:
This study reported grade 3 or higher fatigue, neutropenia with fever, congestive heart failure, and blood clots. However, treatment-related deaths (grade 5 toxicity) were not specifically mentioned.

Results:
The median overall survival rates for groups A and B were 27.3 and 27.2 months, respectively.

Support:
This study was supported by Eli Lilly/ImClone Systems, makers of ramucirumab.

Correspondence: Dr. John R. Mackey; email: john.mackey@trioncology.org

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