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Colon Cancer treatment details. Chemotherapy. Shizuoka Cancer Center, Shizuoka, Japan



Survival: 25.9 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Leucovorin
Country: Japan
   
City/State/Province: Shizuoka
   
Hospital: Shizuoka Cancer Center
   
Journal: Link
   
Date: 1/2015

Description:
Patients:
This phase 2 study involved metastatic colorectal cancer patients who had not received prior chemotherapy. Patients were divided into two separate treatment groups. Group A had 56 patients with a median age of 60.5 years and 58.9% male. Group B consisted of 49 patients with a median age of 61 years and 46.9% male.

Treatment:
Patients in group A received chemotherapy with S-1, oxaliplatin, and leucovorin.

Patients in group B received chemotherapy with leucovorin, fluorouracil, and oxaliplatin (mFOLFOX6).

Toxicities:
The most severe toxicities in group A were of grade 4 and included neutropenia and lymphopenia. Grade 3 nerve toxicity, diarrhea, and anorexia were also reported.

The most severe toxicities in group B were of grade 4 and included neutropenia and lymphopenia. Grade 3 anorexia and febrile neutropenia were also reported.

Results:
The median overall survival rates for groups A and B were 29.9 and 25.9 months, respectively.

Support:
Several of the study’s authors have received funding from various pharmaceutical companies.

Correspondence: Dr. Kentaro Yamazaki; email: k.yamazaki@scchr.jp

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