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Rectal Cancer treatment details. Chemotherapy. University of Chicago, Chicago, Illinois, United States



Survival: 8.3 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Chicago, Illinois
   
Hospital: University of Chicago
   
Journal: Link
   
Date: 6/2004

Description:
Patients: This Phase II trial involved 25 patients with advanced colorectal cancer who had disease progression (increase in tumor size or tumor spread) after being treated with irinotecan-5-fluorouracil-leucovorin (IFL).

Treatment: The treatment consisted of B analog, BMS-247550 (a non-taxane microtubulin-stabilizing agent).

Toxicity: There was considerable grade 3/4 hematological toxicity, including neutropenia (48%) and leukopenia (36%). Grade 3/4 non-hematological toxicities included grade 3 hypersensitivity reaction and peripheral neuropathy.

Results: The median overall survival was 36 weeks (8.3 months).

Correspondence: Dr. C. Eng

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