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Melanoma treatment details. Biologic therapy. Dana-Farber Cancer Institute, Boston, MA, United States

Survival: 12.7 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Dana-Farber Cancer Institute
Journal: Link
Date: 11/2014

This phase 2 study involved metastatic melanoma patients who were divided into two separate treatment groups. Group A consisted of 123 patients with a median age of 61 years; 69.1% were male. Group B had 122 patients with a median age of 64 years; 63.9% were male.

Patients in group A received biologic therapy with ipilimumab (a monoclonal antibody that blocks the CTLA-4 protein) and immunotherapy with sargramostim (GM-CSF), which stimulates the immune system.

Patients in group B received biologic therapy with ipilimumab alone.

There were two treatment-related deaths in group A due to cardiac arrest and colon perforation.

There were seven treatment-related deaths in group B due to colon failure, multiorgan failure, respiratory failure, and kidney failure.

The median overall survival for groups A and B were 17.5 and 12.7 months, respectively.

This study was partially supported by Bristol-Myers Squibb and Genzyme.

Correspondence: Dr. F. Stephen Hodi; email:

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