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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Hormone. Mansoura University, Mansoura, Egypt



Survival: 51.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Hormone
   
Drugs:
Country: Egypt
   
City/State/Province: Mansoura
   
Hospital: Mansoura University
   
Journal: Link
   
Date: 11/2014

Description:
Patients:
This study involved HCV-positive diffuse large B-cell lymphoma patients who were divided into two separate treatment groups. Group A consisted of 200 patients with an average age of 53.6 years; 59.5% were male. Group B had 80 patients with an average age of 53.9 years; 60% were male.

Treatment:
Patients in group A were given chemotherapy (including cyclophosphamide, doxorubicin, and vincristine), the steroid hormone prednisone, and biologic therapy with rituximab.

Patients in group B were given chemotherapy (including cyclophosphamide, doxorubicin, and vincristine), and the steroid hormone prednisone.

Toxicities:
Study-related deaths due to heart failure and liver failure were reported for group A. Grade 4 liver toxicity was also reported.

Study-related deaths due to heart failure and liver failure were reported for group B. Grade 4 liver toxicity was also reported.

Results:
The median overall survival rates for groups A and B were 51 and 43 months, respectively.

Correspondence: Dr. Manal A. Salah-Eldin; email: manasalah@mans.edu.eg

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