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Rectal Cancer treatment details. Chemotherapy. National Cancer Center Hospital, Tokyo, Japan

Survival: 11.8 months
Toxicity Grade: 3
Treatments: Chemotherapy
Country: Japan
City/State/Province: Tokyo
Hospital: National Cancer Center Hospital
Journal: Link
Date: 6/2004

Patients: This Phase II study involved 38 patients with previously untreated metastatic colorectal carcinoma.

Treatment: The treatment consisted of oral fluoropyrimidine S-1 (a combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate).

Toxicity: Grade 3 toxicities included: anemia, neutropenia, diarrhea, and abnormal bilirubin levels. Grade 1 or 2 toxicities included: myelosuppression and gastrointestinal toxicity;.

Results: The median survival time was 358 days (11.8 months).

Support: The study was supported by Taiho Pharmaceutical Co. Taiho Pharmaceutical Co. manufactures fluoropyrimidine S-1.

Correspondence: Kuniaki Shirao, MD

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