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Prostate Cancer treatment details. Radiation. Mount Vernon Cancer Centre, Middlesex, United Kingdom

Survival: 14.4 months
Toxicity Grade: 5
Treatments: Radiation
Country: United Kingdom
City/State/Province: Middlesex
Hospital: Mount Vernon Cancer Centre
Journal: Link
Date: 11/2014

This phase 3 study involved castration-resistant prostate cancer patients with bone metastases who were divided into two groups based on prior treatment. Group A had 352 patients with a median age of 68 years who had been previously treated with docetaxel. Group B had 262 patients with a median age of 74 years who were not previously treated with docetaxel.

Patients in groups A and B received radiation therapy with radium-223 dichloride.

Treatment-related deaths due to unspecified causes were reported for group A. Grade 4 anemia, neutropenia, and fatigue were also reported.

Treatment-related deaths due to thrombocytopenia and other unspecified causes were reported for group B. Grade 4 anemia and fatigue were also reported.

The median overall survival rates for groups A and B were 14.4 and 16.1 months, respectively.

This study was supported by Algeta ASA and Bayer HealthCare Pharmaceuticals.

Correspondence: Dr. Peter Hoskin; email:

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