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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Harvard Medical School, Boston, MA, United States

Survival: 9.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Harvard Medical School
Journal: Link
Date: 1/2015

This phase 2 study involved patients who were divided into groups based on their cancer type. Group A consisted of 24 glioblastoma patients with median age of 53 years; 41.7% were female. Group B had 15 anaplastic glioma patients with a median age of 48 years; 33.3% were female.

Patients in groups A and B received chemotherapy with panobinostat and biologic therapy with bevacizumab.

The most severe toxicities in group A were of grade 4 and included brain hemorrhage and pulmonary embolism.

The most severe toxicities in group B were of grade 4 and included low blood phosphate levels and neutropenia.

The median overall survival for groups A and B was 9 and 17 months, respectively.

This study was supported by Novartis and Genentech.

Correspondence: Dr. Patrick Y.Wen; email:

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