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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Harvard Medical School, Boston, MA, United States



Survival: 17.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Harvard Medical School
   
Journal: Link
   
Date: 1/2015

Description:
Patients:
This phase 2 study involved patients who were divided into groups based on their cancer type. Group A consisted of 24 glioblastoma patients with median age of 53 years; 41.7% were female. Group B had 15 anaplastic glioma patients with a median age of 48 years; 33.3% were female.

Treatment:
Patients in groups A and B received chemotherapy with panobinostat and biologic therapy with bevacizumab.

Toxicities:
The most severe toxicities in group A were of grade 4 and included brain hemorrhage and pulmonary embolism.

The most severe toxicities in group B were of grade 4 and included low blood phosphate levels and neutropenia.

Results:
The median overall survival for groups A and B was 9 and 17 months, respectively.

Support:
This study was supported by Novartis and Genentech.

Correspondence: Dr. Patrick Y.Wen; email: patrick_wen@dfci.harvard.edu

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