Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results

Click here to go back to your search results.

Rectal Cancer treatment details. Biologic therapy. Chemotherapy. Royal Free and University College Medical School, London, United Kingdom

Survival: N/R
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United Kingdom
City/State/Province: London
Hospital: Royal Free and University College Medical School
Journal: Link
Date: 8/2002

Patients: This Phase I study involved 27 patients of which 25 had advanced colorectal cancer.

Treatment: The treatment consisted of antibody-directed enzyme prodrug therapy (ADEPT) in which a prodrug (bis-iodo phenol mustard, ZD2767P) is activated selectively at the tumour site by an enzyme, which has been targeted to the tumour by an antibody (antibody-enzyme conjugate).

Toxicity: Patients in this maximum tolerated dose study experienced grade 4 thrombocytopenia. Other toxicities included neutropenia, leucopenia, nausea, malaise, and fever.

There were no objective responses in this study.

Support: This study was supported by AstraZeneca.

Correspondence: R.J. Francis

E-mail to a Friend Email Physician More Information