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Melanoma treatment details. Biologic therapy. Chemotherapy. St. Mary's Medical Center, San Francisco, CA, United States



Survival: 16.8 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: San Francisco, CA
   
Hospital: St. Mary's Medical Center
   
Journal: Link
   
Date: 2/2015

Description:
Patients:
This phase 2 study involved 50 metastatic melanoma patients who had not received prior chemotherapy. The median patient age was 62 years and 64% were male.

Treatment:
Patients received chemotherapy with nab-paclitaxel and biologic therapy with bevacizumab.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 neutropenia and peripheral neuropathy (nerve toxicity). Bowel perforation, hand-foot skin reaction, and macular edema (swelling of the eye) were also reported.
Results:
The median overall survival was 16.8 months.

Support:
This study was partially supported by Celgene Corporation and Genentech/Roche.

Correspondence: Dr. Lynn E. Spitler; email: ls@drspitler.com

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