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Melanoma treatment details. Biologic therapy. Chemotherapy. University of California, San Francisco, CA, United States



Survival: 14.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: San Francisco, CA
   
Hospital: University of California
   
Journal: Link
   
Date: 4/2015

Description:
Patients:
This phase 2 study involved 38 BRAF wild-type melanoma patients, 68% of whom were male. No age information was provided.

Treatment:
Patients received biologic therapy with axitinib (an inhibitor of the VEGF protein that interferes with cancer cell growth) and chemotherapy with paclitaxel and carboplatin.

Toxicities:
The most severe toxicities were grade 4 neutropenia. Grade 3 nerve toxicity and heart failure were also reported.

Results:
The median overall survival was 14 months.

Support:
This study was supported by Pfizer.

Correspondence: Dr. AI Daud; email: adil.daud@ucsf.edu

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