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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Hormone. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 17.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Hormone
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 3/2015

Description:
Patients:
This phase 2 study involved 30 elderly relapsed or refractory diffuse large B-cell lymphoma patients who were previously treated. The median patient age was 76 years (range of 69-88 years) and 47% were male.

Treatment:
Patients received chemotherapy with vorinostat, cyclophosphamide and etoposide, biologic therapy with rituximab, and the steroid hormone prednisone.

Toxicities:
There was one death on study due to brain hemorrhage. Grade 4 neutropenia and infection, and grade 3 fatigue were also reported.

Results:
The median overall survival was 17.5 months.

Support:
This study was supported by Merck & Co., Inc.

Correspondence: Dr. David J. Straus; email: strausd@mskcc.org

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