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Brain Cancer treatment details. Biologic therapy. Columbia University Medical Center, New York, NY, United States



Survival: 8.9 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Columbia University Medical Center
   
Journal: Link
   
Date: 7/2015

Description:
Patients:
This phase 2 study involved 29 recurrent glioblastoma patients who had been previously treated with surgery, radiation, and temozolomide chemotherapy. The median patient age was 54 years and 59% were male.

Treatment:
Patients received biologic therapy with dasatinib, which is a tyrosine kinase inhibitor.

Toxicities:
The most severe toxicity was grade 4 confusion. Grade 3 fatigue, anorexia, and lymphopenia were also reported.

Results:
The median overall survival was 8.9 months.

Support:
This study was partially supported by Bristol Myers Squibb.

Correspondence: Dr. Andrew B. Lassman; email: ABL7@cumc.columbia.edu

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