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Brain Cancer treatment details. Chemotherapy. Radiation. Dana Farber Cancer Institute , Boston, MA, United States



Survival: 15.9 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Dana Farber Cancer Institute
   
Journal: Link
   
Date: 4/2015

Description:
Patients:
This phase 2 study involved newly diagnosed glioblastoma patients who were divided into two separate treatment groups. Group A consisted of 36 patients with a median age of 55 years, and 52.8% were female. Group B had 70 patients with a median age of 59 years, and 37.1% were female.

Treatment:
Patients in group A received radiation therapy and chemotherapy with temozolomide.

Patients in group B received radiation therapy, chemotherapy with temozolomide, and biologic therapy with vandetanib (a tyrosine kinase inhibitor).

Toxicities:
The most severe toxicities in group A were of grade 4 and included grade 3+ lymphocytopenia, neutropenia, and liver toxicity.

There was one treatment-related death due to pneumonia in group B. Grade 3+ lymphocytopenia, liver toxicity, and fatigue were also reported.

Results:
The median overall survival times for groups A and B were 15.9 and 16.6 months, respectively.

Support:
This study was supported by AstraZeneca.

Correspondence: Dr. Patrick Y. Wen; email: patrick_wen@dfci.harvard.edu

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