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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Dnepropetrovsk Medical Academy , Dnepropetrovsk , Ukraine



Survival: 14.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Ukraine
   
City/State/Province: Dnepropetrovsk
   
Hospital: Dnepropetrovsk Medical Academy
   
Journal: Link
   
Date: 5/2015

Description:
Patients:
This phase 2 study involved 38 advanced/metastatic squamous non-small-cell lung cancer patients who had not received prior chemotherapy. The median patient age was 59.5 years and 89.5% were male.

Treatment:
Patients received biologic therapy with axitinib (a tyrosine kinase inhibitor that interferes with cancer cell growth) and chemotherapy with cisplatin and gemcitabine.

Toxicities:
Treatment-related deaths due to lung hemorrhage, cerebrovascular accident (i.e. stroke), and multiple organ failure were reported. Grade 3-4 neutropenia, anemia and fatigue were also reported.

Results:
The median overall survival was 14.2 months.

Support:
This study was supported by Pfizer Inc.

Correspondence: Dr. Igor M Bondarenko; email: oncology@dsma.dp.ua

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