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Mesothelioma Cancer treatment details. Biologic therapy. University of California Irvine School of Medicine , Orange, CA, United States



Survival: 6.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Orange, CA
   
Hospital: University of California Irvine School of Medicine
   
Journal: Link
   
Date: 2/2015

Description:
Patients:
This phase 2 study involved 59 malignant pleural mesothelioma patients who had received prior treatment. The median patient age was 67 years and 76% were male.

Treatment:
Patients received biologic therapy with everolimus, which is an inhibitor of mTOR that interferes with cancer cell growth.

Toxicities:
There was one death that was possibly treatment-related due to dyspnea (shortness of breath). Grade 3 or higher fatigue, mucositis (inflammation of the lining of the digestive tract), and lung infection were also reported.

Results:
The median overall survival was 6.3 months.

Support:
This study was partially supported by Novartis Pharmaceuticals, Inc.

Correspondence: Dr. Sai-Hong Ignatius Ou; email: siou@uci.edu

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