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Mesothelioma Cancer treatment details. Biologic therapy. University of California Irvine School of Medicine , Orange, CA, United States

Survival: 6.3 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Orange, CA
Hospital: University of California Irvine School of Medicine
Journal: Link
Date: 2/2015

This phase 2 study involved 59 malignant pleural mesothelioma patients who had received prior treatment. The median patient age was 67 years and 76% were male.

Patients received biologic therapy with everolimus, which is an inhibitor of mTOR that interferes with cancer cell growth.

There was one death that was possibly treatment-related due to dyspnea (shortness of breath). Grade 3 or higher fatigue, mucositis (inflammation of the lining of the digestive tract), and lung infection were also reported.

The median overall survival was 6.3 months.

This study was partially supported by Novartis Pharmaceuticals, Inc.

Correspondence: Dr. Sai-Hong Ignatius Ou; email:

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