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Rectal Cancer treatment details. Chemotherapy. Surgery. Saint John's Health Center, Santa Monica, California, United States



Survival: 30.6 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Surgery
   
Drugs: Camptosar
FUDR
Country: United States
   
City/State/Province: Santa Monica, California
   
Hospital: Saint John's Health Center
   
Journal: Link
   
Date: 3/2002

Description:
Patients: This Phase II study involved 185 patients with unresectable colorectal hepatic (liver) metastases that had gotten worse (i.e. progressed by CT and/or CEA levels) while these patients received the chemotherapy 5-FU. For all patients the cancer was adenocarcinoma of the colon or rectum.

Treatment: The patients were divided into two groups: Group 1 comprised 114 patients who received cytoreductive surgery alone; Group 2 comprised 71 patients who received cytoreductive surgery plus hepatic arterial floxuridine (FUDR) and systemic irinotecan (camptosar) two chemotherapy drugs.

Toxicity: Perioperative mortality was 2%. Of all patients, 1% developed renal failure, 1% developed multisystem organ failure, and 5% developed respiratory failure requiring prolonged intubation. Other toxicities included: increase in enzyme levels, neutropenia and diarrhea. Sixty percent of patients required a dose reduction in FUDR.

Results: For Group 2 (patients who received the additional chemotherapy), the median survival (estimated from the time of surgery) was 30.6 months.

Correspondence: Anton J. Bilchik, MD, PhD

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