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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. University of Rochester, Rochester, NY, United States



Survival: 8.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, NY
   
Hospital: University of Rochester
   
Journal: Link
   
Date: 7/2015

Description:
Patients:
This phase 2 study involved 37 peripheral T Cell lymphoma patients who had been previously treated. The median patient age was 62 years and 65% were male.

Treatment:
Patients received biologic therapy with alisertib, an oral aurora A kinase (AAK) inhibitor.

Toxicities:
There was one treatment-related death due to grade 5 sepsis (infection). Grade 3 or higher neutropenia, mucositis (inflammation of the lining of the digestive tract), and anemia were also reported.

Results:
The median overall survival was 8 months.

Correspondence: Dr. Paul M. Barr; email: paul_barr@urmc.rochester.edu

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