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Rectal Cancer treatment details. Chemotherapy. University of Oxford, Oxford, United Kingdom



Survival: 14.7 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Leucovorin
Country: United Kingdom
   
City/State/Province: Oxford
   
Hospital: University of Oxford
   
Journal: Link
   
Date: 2/2003

Description:
Patients: 290 patients with colorectal cancer with metastases confined to the liver were involved in this study. Patients were divided into two groups: an intrahepatic treatment group composed of 145 patients and an intravenous group composed of 145 patients.

Treatment: For the intrahepatic group the treatment consisted of the administration of intrahepatic arterial (IHA) fluorouracil (5-FU, adrucil)and folinic acid (leucovorin).

Toxicity: One patient died from gastrointestinal hemorrhage from a bleeding ulcer after receiving 15 cycles of IHA therapy. Grade 3 or 4 toxicities were rare and included: nausea, vomiting, anorexia, stomatitis, and diarrhea.

Results: Median overall survival was 14.7 months.

Correspondence: Prof. David J. Kerr

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