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Rectal Cancer treatment details. Chemotherapy. University of Texas Medical Branch, Galveston, Texas, United States



Survival: 17.4 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Leucovorin
Country: United States
   
City/State/Province: Galveston, Texas
   
Hospital: University of Texas Medical Branch
   
Journal: Link
   
Date: 11/2004

Description:
Patients: This Phase II study involved 28 patients with advanced colorectal cancer with distant metastases.

Treatment: Treatment consisted of three drugs 5-FU (adrucil), leucovorin, and PALA (a type of enzyme inhibitor).

Toxicity: One patient died of a treatment related infection. Grade 3-4 toxicities included: diarrhea, nausea, vomiting, anemia, leucopenia, thrombocytopenia, infection, bilirubin increase, dyspnea, hypercalcemia, and stomatitis.

Results: Estimated median survival was 17.4 months.

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