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Rectal Cancer treatment details. Chemotherapy. Radiation. Surgery. Duke University Medical Center, Durham, North Carolina, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
Surgery
   
Drugs: Adrucil
Country: United States
   
City/State/Province: Durham, North Carolina
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 3/2004

Description:
Patients: This Phase I study involved 21 patients with locally advanced or unresectable adenocarcinoma of the rectum and colon.

Treatment: Treatment consisted of the chemotherapy drugs eniluracil and 5-FU (adrucil) with radiotherapy followed by surgery.

Toxicity: Grade 3-4 toxicities included diarrhea and nausea. Grade 1-2 toxicities included vomiting, fatigue, anorexia, rectal pain, cystitis, hematologic, and hyperbilirubinemia.

Results: One patient achieved a complete response. Overall survival was not discussed.

Support: This study was funded by GlaxoSmith Kline.

Correspondence: Herbert I. Hurwitz, MD

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