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Breast Cancer treatment details. Chemotherapy. University Hospital of Helsinki, Helsinki, Finland



Survival: 7.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Methotrexate
Navelbine
Country: Finland
   
City/State/Province: Helsinki
   
Hospital: University Hospital of Helsinki
   
Journal: Link
   
Date: 5/2003

Description:
Patients: This Phase II trial involved a total of 60 patients with metastatic breast cancer. Patients were divided into three groups (Groups 1-3). Group 1 had 26 patients, group 2 had 24 patients, and group 3 had 10 patients.

Treatment: Each of the three groups received the same three chemotherapy drugs vinorelbine (navelbine), methotrexate and fluorouracil (5-FU, adrucil). However, the groups received them in different doses and schedules.

Toxicity: The toxicity for patients in group 1 included grade 1-4 hematological toxicities, and grade 1-3 alopecia and infection. Other toxicities (less than grade 3) included constipation, diarrhea, local irritation, nausea, neurotoxicity, pain, and stomatitis.

Results: Median survival time was 7 months for patients in group 1.

Correspondence: Prof. I. Elomaa

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