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Breast Cancer treatment details. Chemotherapy. University Hospital of Helsinki, Helsinki, Finland

Survival: 10.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Navelbine
Country: Finland
City/State/Province: Helsinki
Hospital: University Hospital of Helsinki
Journal: Link
Date: 5/2003

Patients: This Phase II trial involved a total of 60 patients with metastatic breast cancer. Patients were divided into three groups (Groups 1-3). Group 1 had 26 patients, group 2 had 24 patients, and group 3 had 10 patients.

Treatment: Each of the three groups received the same three chemotherapy drugs vinorelbine (navelbine), methotrexate and fluorouracil (5-FU, adrucil). However, the groups received them in different doses and schedules.

Toxicity: The toxicity for patients in group 2 included grade 1-4 hematological toxicities, grade 2-4 infection, and grade 1-3 constipation, nausea, pain, and infection. Other toxicities (less than grade 3) included alopecia, diarrhea, local irritation, neurotoxicity, and stomatitis.

Results: Median survival time was 10 months for patients in group 2.

Correspondence: Prof. I. Elomaa

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