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Breast Cancer treatment details. Chemotherapy. UCLA Medical Center, Los Angeles, California, United States

Survival: 21.7 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Adriamycin
Country: United States
City/State/Province: Los Angeles, California
Hospital: UCLA Medical Center
Journal: Link
Date: 3/2003

Patients: This Phase III study involved a total of 429 patients with metastatic breast cancer. Patients were divided into two groups group 1 comprised 214 patients (213 received treatment); and group 2 comprised was of 215 patients (210 received treatment).

Treatment: Patients in group 1 were administered two chemotherapy drugs doxorubicin (adriamycin) and docetaxel (taxotere). Patients in group 2 were administered two chemotherapy drugs doxorubicin (adriamycin) and cyclophosphamide (cytoxan).

Toxicity: Four patient in group 2 died from one from infection and three from congestive heart failure. Other toxicities included grade 3-4 hematologic toxicity, nausea, vomiting, stomatitis, diarrhea, and asthenia.

Results: Median survival for patients in group 2 was 21.7 months.

Support: The study was supported by Aventis Pharma.

Correspondence: Jean-Marc Nabholtz, MD

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