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Breast Cancer treatment details. Chemotherapy. Oncology and Hematology Associates, Indianapolis, Indiana, United States

Survival: 18.4 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Adrucil
Country: United States
City/State/Province: Indianapolis, Indiana
Hospital: Oncology and Hematology Associates
Journal: Link
Date: 1/2003

Patients: This Phase II trial involved 155 patients with metastatic breast cancer.

Treatment: The treatment involved administration of three drugs paclitaxel (taxol) 5-fluorouracil (adrucil), and leucovorin. (The drugs were administered on two different schedules to the patients.)

Toxicity: Sepsis occurred in two patients, with one of these patients having a septic death that was likely treatment related. Other toxicities included grade 3-4 hematological toxicity, neuropathy, diarrhea, and asthenia.

Results: The median overall survival for all patients was 18.4 months.

Support: The study was supported in part by Bristol-Myers Squibb Oncology. Bristol-Myers Squibb markets taxol.

Correspondence: David M. Loesch, MD

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