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Breast Cancer treatment details. Chemotherapy. Columbia University/New York Presbyterian Hospital, New York, New York, United States

Survival: 17.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Emcyt
Country: United States
City/State/Province: New York, New York
Hospital: Columbia University/New York Presbyterian Hospital
Journal: Link
Date: 2/2003

Patients: This Phase II trial involved 31 (assessable) patients with metastatic breast cancer. Patients had been treated previously with hormonal therapy and/or chemotherapy and/or radiation therapy.

Treatment: The treatment consisted of two chemotherapy drugs docetaxel (taxotere) and estramustine (emcyt).
Toxicity: Grade 4 toxicities included hematologic, neurosensory, pulmonary, hyperglycemia, and auditory. Grade 1-3 toxicities included: nausea, edema, emesis, fatigue, diarrhea, stomatitis, infection, focal dermatitis, vaginal bleeding, myalgia, GI bleed, fever, epistaxis, hyponatremia, and hot flashes.

Results: Median overall survival was 17 months.

Support: This study was supported in part by Aventis Pharmaceuticals. Aventis markets taxotere.

Correspondence: Amy D. Tiersten, MD

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