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Breast Cancer treatment details. Chemotherapy. Baylor-Sammons Cancer Center, Dallas, Texas, United States

Survival: 11.5 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Taxotere
Country: United States
City/State/Province: Dallas, Texas
Hospital: Baylor-Sammons Cancer Center
Journal: Link
Date: 6/2002

Patients: This Phase III study involved 511 women with metastatic breast cancer or breast cancer that was unresectable and locally advanced. Patients were divided into two groups: Group A contained 255 patients, and Group B contained 256 patients.

Treatment: The treatment for patients in group A consisted of two chemotherapy drugs – docetaxel and capecitabine. The treatment for patients in group B consisted of only docetaxel (taxotere).

Toxicity: In Group B, one patient died of neutropenic sepsis that was “probably” related to treatment. In addition, grade 3-4 toxicities included: neutropenic fever, stomatitis, diarrhea, nausea, hand-foot syndrome, alopecia, and fatigue/asthenia.

Results: Median survival for patients in Group B was 11.5 months.

Support: This research was supported by F. Hoffman-La Roche. In addition, some of the study’s authors have received monetary compensation (over $2,000/year) from F. Hoffman-La Roche or Aventis, or both. Aventis markets taxotere.

Correspondence: Joyce O'Shaughnessy, MD

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