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Breast Cancer treatment details. Churchill Hospital, Oxford, United Kingdom

Survival: 9.4 months
Toxicity Grade: 4
Country: United Kingdom
City/State/Province: Oxford
Hospital: Churchill Hospital
Journal: Link
Date: 5/2002

Patients: This Phase II study involved 44 women with advanced and/or metastatic breast cancer. Most patients had been treated previously with other regimens. Patients were divided into two groups 22 in Group A and 20 in Group B. (Two patients were part of a third group that was discontinued.)

Treatment: Patients in group A were administered the oral drug capecitabine. Patients in group B were treated with the intravenous drug paclitaxel (taxol).

Toxicity: In group B, there was grade 4 neutropenia. Other toxicities included: leucopenia, thrombocytopenia, nausea, alopecia, diarrhea, vomiting, paraesthesia, fatigue, stomatitis, pyrexia, mylagia, and peripheral neuropathy.

Results: Median survival was 9.4 months for patients in group B.

Support: This study was sponsored by F. Hoffmann-La Roche

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