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Breast Cancer treatment details. Hormone. M.D. Anderson Cancer Center , Dallas, Texas, United States

Survival: ?
Toxicity Grade: 3
Treatments: Hormone
Country: United States
City/State/Province: Dallas, Texas
Hospital: M.D. Anderson Cancer Center
Journal: Link
Date: 3/2003

Patients: This Phase II study involved 112 women with locally advanced or metastatic breast cancer.

Treatment: The treatment consisted of the drug arzoxifene (LY353381). (Arzoxifene is a selective estrogen receptor modulator.) Patients were divided into two groups and each group received arzoxifene at a different dose.

Toxicity: Grade 3 toxicities included nausea, cutaneous toxicity, neuromotor toxicity, “neuroheadache,” and vomiting.

Results: The median time to progression (when tumors grow and/or spread) was 2.7-2.8 months. A survival analysis was not performed.

Support: This study was sponsored by Eli Lilly and Company

Correspondence: Aman Buzdar, MD

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