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Lung Cancer treatment details. Chemotherapy. National Cancer Center Hospital, Tokyo, Japan



Survival: 10.1 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Camptosar
Platinol
Vepesid
Country: Japan
   
City/State/Province: Tokyo
   
Hospital: National Cancer Center Hospital
   
Journal: Link
   
Date: 3/2003

Description:
Patients: This Phase I/II trial involved 56 patients with a median age of 56 years. Forty-five patients had non-small-cell lung cancer (majority with adenocarcinoma) and eleven patients had small cell lung cancer. None of the patients had prior chemotherapy.

Treatment: The treatment consisted of the administration of three drugs irinotecan (camptosar), cisplatin (platinol), and etoposide (VP-16, vepesid).

Toxicity: There was grade 4 hematologic toxicity. Other toxicities (grade 1-3) included elevated enzymes, elevated creatinine, hyponatremia, hypokalemia, infection, nausea/vomiting, diarrhea, stomatitis, and alopecia.

Results: The median survival time for the 45 patients with non-small-cell lung cancer was 10.1 months.

Correspondence: Dr. I. Sekine

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