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Mesothelioma Cancer treatment details. Biologic therapy. Massachusetts General Hospital, Boston, Massachusetts , United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, Massachusetts
   
Hospital: Massachusetts General Hospital
   
Journal: Link
   
Date: 2/2001

Description:
Patients: This Phase I study involved 21 patients with a variety of different solid tumors. Two of the 21 patients had mesothelioma.

Treatment: The treatment consisted of the administration of an extract (Ecteinascidin 743 (ET-743) a cytotoxic tetrahydroisoquinoline alkaloid) from a marine animal called a tunicate (Ecteinascidia turbinate).

Toxicity: Grade 3-4 toxicities included hematologic, transaminitis, cardiac, rhabdomyolysis, renal, fatigue and nausea/vomiting.

Results: One of the two mesothelioma patients had a 41% reduction by CT scan in the size of disease in the mediastinal lymph nodes and a pulmonary nodule. This patientís cancer ultimately grew. Overall survival was not discussed.

Support: Research support came from PharmaMar S.A. This company markets ET-743.

Correspondence: David P. Ryan, MD

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