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Lung Cancer treatment details. Chemotherapy. Centre Hospitalier Lyon-Sud, Lyon, Italy

Survival: 8.2 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: IFEX
Country: Italy
City/State/Province: Lyon
Hospital: Centre Hospitalier Lyon-Sud
Journal: Link
Date: 12/2002

Patients: This Phase III trial involved a total of 259 patients with metastatic or relapsed non-small cell lung cancer. Patients were divided into two groups: Group A comprised of 133 patients, and Group B comprised of 126 patients.

Treatment: Group A patients were administered two drugs, vinorelbine and cisplatin. (NP) Group B patients were administered three drugs vinorelbine (navelbine), ifosfamide (IFEX), and cisplatin (platinol).

Toxicity: There were 8 toxic deaths in Group B. Other toxicities in this group included hematological (grade 3-4), nausea and vomiting (grade 3-4), elevation of transaminases (grade 3-4), and alopecia.

Results: Median survival in Group B was 8.2 months.

Support: This study was supported by the Institut de Recherche Pierre Fabre.

Correspondence: Dr. P.J. Souquet

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