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Lung Cancer treatment details. Chemotherapy. University of Torino, Turin, Italy



Survival: 9.5 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Navelbine
Platinol
Country: Italy
   
City/State/Province: Turin
   
Hospital: University of Torino
   
Journal: Link
   
Date: 11/2002

Description:
Patients: This Phase III study involved a total of 607 patients with advanced (stage IIIB or IV or recurrent) non-small cell lung cancer. Patients were divided into three groups. Group A comprised 205 patients. Group B comprised 201 patients. Group C comprised 201 patients.

Treatment: Patients in Group C were treated with two drugs vinorelbine (navelbine) and cisplatin (platinol).

Toxicity: In Group C, seven patients died of drug-related causes. Other toxicities included hematological (grade 3-4), peripheral neuropathy (grade 1-3), alopecia (grade 1-2), nausea/vomiting, constipation, renal insufficiency (grade 3 or 4), cardiovascular, and cutaneous.

Results: Overall survival for patients in Group C was 9.5 months.

Support: This study was supported by Eli Lilly and Company.

Correspondence: G.V. Scagliotti, MD

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