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Lung Cancer treatment details. Chemotherapy. Hospital Germans Trias I Pujol Hospital, Badalona, Spain



Survival: 8.2 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Paraplatin
Taxol
Country: Spain
   
City/State/Province: Badalona
   
Hospital: Hospital Germans Trias I Pujol Hospital
   
Journal: Link
   
Date: 10/2002

Description:
Patients: This Phase III study involved 608 patients with advanced (stage IIIB or IV) non-small-cell lung cancer. Patients were divided into two groups. Group A contained 302 patients and Group B contained 306 patients.

Treatment: For patients in Group B, the treatment consisted of two drugs – paclitxel (taxol) and carboplatin (paraplatin). In addition, 42% of patients received follow-up radiotherapy and 24% received another chemotherapy regimen.

Toxicity: Grade 3-4 toxicities in Group B included hematological, infections, and peripheral neuropathy. Other toxicities included arthralgia/myalgia, asthenia, ototoxicity, nausea/vomiting, diarrhea, and renal toxicity.

Results: Median survival was 8.2 months for patients in Group B.

Support: This study was supported by Bristol-Myers Squibb. In addition, two of the study’s authors are affiliated with Bristol-Myers Squibb.

Correspondence: Dr. R. Rosell

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