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Brain Cancer treatment details. Chemotherapy. Azienda Ospedale-Universita Ospedale Busonera, Padua, Italy



Survival: 11.2 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Platinol
Temodar
Country: Italy
   
City/State/Province: Padua
   
Hospital: Azienda Ospedale-Universita Ospedale Busonera
   
Journal: Link
   
Date: 5/2004

Description:
Patients: This Phase II study involved 50 patients with glioblastoma multiforme who had experienced disease recurrence or progression after surgery and standard radiotherapy, and had not been administered chemotherapy before.

Treatment: Treatment consisted of two chemotherapy drugs cisplatin (platinol) and temozolomide (temodar).

Toxicity: Toxicities included one irreversible heart failure, one pulmonary embolism leading to death, and one arterial embolism with leg amputation. Grade 3-4 toxicities included: neutropenia and thrombocytopenia. Grade 3 toxicities included: anemia, neurotoxicity, ototoxicity.

Results: Median survival time was 11.2 months.

Correspondence: Alba A. Brandes, MD

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