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Lung Cancer treatment details. Chemotherapy. The Sarah Cannon Cancer Center and Tennessee Oncology, Nashville, Tennessee, United States



Survival: 8.7 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Gemzar
Taxol
Country: United States
   
City/State/Province: Nashville, Tennessee
   
Hospital: The Sarah Cannon Cancer Center and Tennessee Oncology
   
Journal: Link
   
Date: 9/2002

Description:
Patients: This Phase II study involved a total of 267 patients with advanced (Stage IIIB and IV) non-small-cell lung carcinoma. Patients were divided into 4 groups: Group A contained 71 patients; Group B contained 65 patients; Group C contained 64 patients; Group D contained 67 patients.

Treatment: The treatment for patients in Group C consisted of two drugs paclitaxel (taxol) and gemcitabine (gemzar).

Toxicity: In total there were 5 treatment related deaths, two of which occurred in Group C. Other toxicities in this group included grade 4 leukopenia and thrombocytopenia, grade 3 anemia, grade 2-3 neuropathy, grade 2 alopecia, grade 2-3 nausea/vomiting, grade 2-3 diarrhea, and grade 3-4 myalgia/arthralgia.

Results: Median survival for patients in Group C was 8.7 months.

Support: This study was supported in part by Bristol Myers Squibb, Eli Lilly and Company, and GlaxoSmithKline.

Correspondence: F. Anthony Greco, MD

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