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Lung Cancer treatment details. Chemotherapy. University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States

Survival: 12.5 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Camptosar
Country: United States
City/State/Province: Chapel Hill, North Carolina
Hospital: University of North Carolina, Chapel Hill
Journal: Link
Date: 10/2002

Patients: This Phase II trial involved 40 patients with advanced (stage IIIB or IV) non-small cell lung carcinoma.

Treatment: The treatment consisted of a three-drug combination of irinotecan (CPT-11, Camptosar), paclitaxel (taxol), and carboplatin (paraplatin).

Toxicity: Grade 2-4 toxicities included hematologic, diarrhea, vomiting, dyspnea, and dehydration. Other toxicities (grade 2-3 included) alopecia, asthenia, nausea, arthralgia, myalgia, and neuropathy.

Results: The median survival was 12.5 months.

Support: This study was supported in part by a grant from Pharmacia Corporation. Pharmacia Corporation markets irinotecan (CPT-11).

Correspondence: Mark A. Socinski, MD

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