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Lung Cancer treatment details. Chemotherapy. Louisiana Oncology Associates, Lafayette, Louisiana, United States



Survival: 7.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Gemzar
Hycamtin
Country: United States
   
City/State/Province: Lafayette, Louisiana
   
Hospital: Louisiana Oncology Associates
   
Journal: Link
   
Date: 9/2002

Description:
Patients: This Phase II study involved 35 patients with unresectable (i.e. inoperable) advanced non-small-cell lung carcinoma. All patients had been previously treated with one chemotherapy regimen prior to this treatment.

Treatment: Treatment consisted of two chemotherapy drugs, topotecan (hycamtin) and gemcitabine (gemzar).

Toxicity: Grade 1-4 toxicities included neutropenia and thrombocytopenia. Other toxicities (grade 1-3) included anemia, fatigue, fever, headache, shortness of breath, nausea/emesis, anorexia, mucositis, dermatitis, arthralgia, and diarrhea.

Results: The overall median survival was 7 months.

Support: This study was supported by a grant from GlaxoSmithKline. GlaxoSmithKline markets topotecan.

Correspondence: David A. Rinaldi, MD

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