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Lung Cancer treatment details. Chemotherapy. Radiation. Mayo Clinic and Mayo Foundation, Rochester, Minnesota, United States



Survival: 14.0 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs: Platinol
Vepesid
Country: United States
   
City/State/Province: Rochester, Minnesota
   
Hospital: Mayo Clinic and Mayo Foundation
   
Journal: Link
   
Date: 10/2002

Description:
Patients: This Phase III study involved 234 patients with stage III non-small-cell lung cancer. Patients were divided into two groups: Group A (117 patients) and Group B (117 patients).

Treatment: For patients in Group B, the treatment consisted of chemotherapy, etoposide (vepesid) and cisplatin (platinol) plus radiotherapy (60 Gray in 30 daily fractions).

Toxicity: In Group B, 3 patients died of acute toxicity (pneumonitis, infection, and renal failure). Other toxicities included grade 3-4 leukopenia, thrombocytopenia, nausea, vomiting, esophagitis, pneumonitis, and dyspnea.

Results: Median survival time for patients in Group B was 14 months.

Correspondence: Steven E. Schild, MD

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