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Lung Cancer treatment details. Chemotherapy. Surgery. University of Rochester Medical Center, Rochester, New York, United States



Survival: 19.4 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Surgery
   
Drugs: Platinol
Country: United States
   
City/State/Province: Rochester, New York
   
Hospital: University of Rochester Medical Center
   
Journal: Link
   
Date: 10/2002

Description:
Patients & Treatment: This Phase III study involved a total of 73 patients with stage IIIA non-small-cell lung cancer. Patients were divided into 5 groups. Group 1 (7 patients) received three drugs (cisplatin (platinol), vinblastine (velban), and mitomycin-C) in conjunction with surgery. Group 2 (9 patients) received the same drugs in conjunction with radiotherapy. Group 3 (12 patients) received only the drugs cisplatin and vinblastine. Group 4 (22 patients) received two drugs (cisplatin and vinblastine) with surgery. Group 5 (23 patients) received two drugs (cisplatin and vinblastine) with radiotherapy.

Toxicity: For the surgery plus chemotherapy groups (Groups 1 and 4) there were two toxic deaths (one late pulmonary toxicity and one pulmonary embolus). There were also hematologic toxicities.

Results: For the surgery plus chemotherapy groups (Groups 1 and 4), median survival was 19.4 months.

Correspondence: David W. Johnstone, MD

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