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Kidney Cancer treatment details. Biologic therapy. University of Oxford, Oxford, United Kingdom

Survival: 7.9 months
Toxicity Grade: 2
Treatments: Biologic therapy
Country: United Kingdom
City/State/Province: Oxford
Hospital: University of Oxford
Journal: Link
Date: 11/2004

Patients: This Phase II trial involved 25 patients with metastatic renal cell carcinoma, 17 men and 8 women. The median age was 62. Fifteen had undergone prior nephrectomy.

Treatment: The treatment consisted of a new antiangiogenic agent called IM862 (a naturally occurring dipeptide).

Toxicity: Toxicities “probably related” to the drug included grade 1-2 sinusitis and grade 1 headache. (There were several grade 3 toxicities such as fatigue, pain, and nausea/vomiting, but the authors concluded that “none were related to the study drug.”)

Results: There were no objective responses and the median overall survival was 7.9 months.

Support: One of the authors, G Deplanque was supported by a research grant from Aventis Oncology.

Correspondence: Dr. A.L. Harris

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