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Kidney Cancer treatment details. Biologic therapy. Churchill Hospital, Oxford, United Kingdom



Survival: N/R
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: Oxford
   
Hospital: Churchill Hospital
   
Journal: Link
   
Date: 10/2003

Description:
Patients: This Phase II study involved 16 patients with advanced renal cancer; 11 men and 5 women. Median age was 59. Eight had undergone prior nephrectomy. Most had undergone other previous treatments.

Treatment: The treatment consisted of bryostatin-I. Bryostatin-I is a biological agent that has been isolated from a marine organism the bryzoan, Bigula neritina.

Toxicity: Grade 4 toxicities possibly related to the treatment included dyskinetic tongue movements, hematuria, and skin rash. Other common side effects included myalgia, fatigue, nausea, headache, vomiting, anorexia, anemia and lymphopenia.

Results: No complete responses or partial responses were seen.

Correspondence: Dr. A.L. Harris

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