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Kidney Cancer treatment details. Immunotherapy. Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States



Survival: 13.5 months
   
Toxicity Grade: 4
   
Treatments: Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Cleveland, Ohio
   
Hospital: Cleveland Clinic Taussig Cancer Center
   
Journal: Link
   
Date: 4/2003

Description:
Patients: This Phase I trial involved 25 patients with metastatic renal cell carcinoma; 18 men and 7 women. The median age was 59. All patients had undergone prior systemic treatments and 19 had undergone prior nephrectomy.

Treatment: The treatment consisted of a novel synthetic type of interferon consensus interferon (CIFN).

Toxicity: Grade 3-4 toxicities included hypocalcemia, neutropenia, thrombocytopenia, prolonged PT/PTT, respiratory distress/failure, nausea/vomiting, and syncope.

Results: There were no responses and overall median survival was 13.5 months.

Support: The study was supported by a grant from Amgen. Amgen manufactures CIFN.

Correspondence: Thomas E. Hutson, MD

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