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Kidney Cancer treatment details. Immunotherapy. Edward Hines Jr VA Hospital, Illinois, United States



Survival: 13.0 months
   
Toxicity Grade: 4
   
Treatments: Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Illinois
   
Hospital: Edward Hines Jr VA Hospital
   
Journal: Link
   
Date: 4/2002

Description:
Patients: This Phase II study involved 44 patients with metastatic renal cell carcinoma; 32 men and 12 women. The median age was 56 years. Prior treatments had included nephrectomy (19 patients) and radiation therapy (5 patients).

Treatment: The treatment consisted of immunotherapy interleukin-2 (IL-2) and interferon alpha-2b (IFN alpha-2b).

Toxicity: Grade 3-4 toxicities included hematologic, hyponatremia, hepatic, metabolic, gastrointestinal, nausea, diarrhea, stomatitis, renal, hypotension, neurologic, and dyspnea.

Results: The median survival was 13 months.

Support: The study was supported by grants from Chiron Therapeutics and Schering Plough Corporation. Chiron holds a patent on IL-2 and Schering Plough markets IFN alpha-2b.

Correspondence: Dr. J.I. Clark

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