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Brain Cancer treatment details. Biologic therapy. Radiation. Hoag Cancer Center, Newport Beach, California, United States

Survival: 9.3 months
Toxicity Grade: 3
Treatments: Biologic therapy
Drugs: Roferon-A
Country: United States
City/State/Province: Newport Beach, California
Hospital: Hoag Cancer Center
Journal: Link
Date: 1/2001

Patients: A total of 40 patients comprised of 36 patients with glioblastoma multiforme (or grade 4 anaplastic astrocytoma), and 4 patients with grade 3 anaplastic astrocytoma.

Treatment: The treatment consisted of interferon-alpha2a (Roferon-A) and 13-cis-retinoic acid with radiotherapy.

Toxicity: During the course of the treatment, several patients experienced some worsening of neurologic symptoms that appeared to be due to enhanced radiation effect rather than progression of tumor. Other toxicities included cutaneous toxicity, elevations of enzymes (SGOT and LDH), elevation of serum triglycerides (grade 3), fatigue/malaise, and alopecia (attributable to radiation therapy).

Results: Median overall survival was 9.3 months for all patients. The authors concluded, “The major conclusion from this trial is that concurrent administration of 13-cis-retinoic acid plus Interferon-alpha2a with external beam radiation therapy is unlikely to produce a survival benefit compared with that observed with radiation plus IFN (interferon-alpha2a) or radiation therapy alone.”

Support: Hoffman-LaRoche provided the 13-cis-retinoic acid (Accutaine) and Interferon-alpha2a (Roferon-A).

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