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Kidney Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Survival: N/R
Toxicity Grade: 3
Treatments: Biologic therapy
Drugs: Thalomid
Country: United States
City/State/Province: New York, New York
Hospital: Memorial Sloan-Kettering Cancer Center
Journal: Link
Date: 1/2002

Patients: This Phase II study involved 26 patients with advanced renal cell carcinoma; 23 men and 3 women. The median age was 58. Prior treatments included nephrectomy (15 patients), immunotherapy (15 patients), and radiation therapy (4 patients).

Treatment: The treatment consisted of the drug thalidomide (thalomid), an anti-angiogenesis agent. (Angiogenesis refers to the creation of new blood vessels, which cancers require.)

Toxicity: Grade 3 toxicities included sinus brachycardia, thrombosis, neuropathy, vertigo, and dyspnea.

Results: No patient achieved a partial or complete response.

Support: The study was supported by Celgene Corp. This company markets thalidomide (thalomid).

Correspondence: Robert J. Motzer, MD

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