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Kidney Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Survival: N/R
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: New York, New York
Hospital: Memorial Sloan-Kettering Cancer Center
Journal: Link
Date: 1/2001

Patients: This Phase II trial involved 13 patients with advanced renal cell carcinoma; 9 men and 4 women. Median age was 55 years. Prior therapies included nephrectomy (8 patients), immunotherapy (6 patients), and radiation therapy (4 patients).

Treatment: The treatment consisted of irofulven, an analog of the mushroom derived product illudin S.

Toxicity: Grade 3-4 toxicities included dyspnea, hematologic, gastrointestinal, dehydration, and hallucinations.

Results: There were no major responses and overall survival was not discussed.

Correspondence: Robert J. Motzer, MD

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