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Breast Cancer treatment details. Biologic therapy. Johns Hopkins Oncology Center, Baltimore, Maryland, United States

Survival: N/R
Toxicity Grade: 3
Treatments: Biologic therapy
Country: United States
City/State/Province: Baltimore, Maryland
Hospital: Johns Hopkins Oncology Center
Journal: Link
Date: 10/2001

Patients: This Phase I study involved a total of 27 patients with solid malignancies. Six patients had advanced breast cancer.

Treatment: Treatment consisted of an inhibitor (BAY12-9566) of matrix metalloproteinases, a family of proteolytic enzymes.

Toxicity: One patient developed cardiac arrest related to hyperkalemia. Other toxicities included grade 2 bilirubin toxicity, grade 2 alkaline phosphatase toxicity, deep vein thrombosis, grade 1 headaches, grade 3 musculoskeletal back pain, and grade 3 nausea and vomiting.

Results: No responses were seen and survival was not discussed.

Correspondence: E.I. Heath, MD

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